Clinical Studies

The Quantitative Suspension Test: Manorapid Synergy effectiveness against Avian Influenza Virus
Study by Prof. Dr. Erhard F. Kaleta and Dr. A. Yilmaz, Clinic for Birds, Reptiles, Amphibia and Fish.
Justus Liebig University Gleesen, Feb. 9, 2004.
Avian Influenza A Virus H5NI, tested by standard suspension test in vitro effective in 15 seconds.
F.D.A. - Section 333.470 Testing of health care antiseptic drug products, Tentative Final Monograph for Health Care Antiseptic Drug Products, Hygiene Center and Medical Products
Study by Prof. Dr. Medicine, H. P. Werner. March
Gels vs. Liquids Comparisons
Limited efficacy of alcohol-based hand gels
Study by Axel Kramer, Peter Rudolph, Gonter Kampf, and Didier Pittet.
Institute for Hygiene and Environmental Medicine, University of Greifswald, Greifswald, Germany (A Kramer MD, P Rudolph MD); Bode Chemie GmbH, Scientific Affairs, Hamburg, Germany (G Kampf MD); and Infection Control Programme, Department of Internal Medicine, University of Geneva HospitaIs, 1211 Geneva 14, Switzerland (Prof D Pittet MD)
**Contributed References and reports to: The Lancet, Vol 359, April 27, 2002.
Hand disinfection in ward and operating room with soaps, rinses or gels
Study by Manfred L. Rotter
Division of Hygiene and Medical Microbiology of the University of Vienna. CHICA Conference, Thunderbay. June 24, 2003
Comparison of the Liquid alcohol-based hand antiseptic products with alcohol-based hand gels
Study by G. Strunc, Microbiologist, Health Canada (Retired).
Surgical hand disinfection - different approaches
Manfred L. Rotter
Institsute of Hygiene and Medical Microbiology, Medical University Vienna, 10-20-04
Hand antiseptics: rubs versus scrubs, alcoholic solutions versus alcoholic gels
Study by H. Pietsch
Journal of Hospital Infection



Effectiveness of the Vira-Block (Manorapid Synergy) Formula
Rotavirus efficacy of Manorapid Synergy
Study by Dr. Jochen Steinmann
Performed at Mikrolab GmbH; Antiseptica, Chemisch-pharmazeutische Produkte GmbH, Carl-Friedrich-GauB-Str. 7; 50259 Pulheim / Brauweilier
Testing for Virucidal Activity of Manorapid Synergy (Antiseptica) vs. bovine rotavirus (BRV),
Head of the research team: Prof. Angel S. Galabov, M.D., D.Sc.
Performed in the Stephan Angeloff Institute of Microbiology (Department of Virology), Bulgarian Academy of Sciences (Sofia, Bulgaria). May 2004.
Bovine Rotavirus tested utilizing suspension test in vitro (test tube) effective in 30 seconds.
F.D.A. — Section 333.470 Testing of health care antiseptic drug products, Tentative Final Monograph for Health Care Antiseptic Drug Products, Hygiene Center and Medical Products
Study by Prof. Dr. Medicine, H. P. Werner. March 2004.
F.D.A.: Testing protocol, antibiotic style test approximately 1,000 individual tests required to complete test regeime.
Testing for Virucidal Activity of Manorapid Synergy (Antiseptica) vs. human rhinovirus 14 (HRV14) and bovine viral diarrhea virus (BVDV), a surrogate hepatitis C virus.
Head of the research team: Prof. Angel S. Galabov, M.D., D.Sc.
Performed in the Stephan Angeloff Institute of Microbiology (Department of Virology), Bulgarian Academy of Sciences (Sofia, Bulgaria). July 2003.
Contact suspension test in vitro used to determine virucidal activity against Rhinovirus (cold) and Bovine virus (Hepatitis C), effective in 15 to 30 seconds.
Efficiency of Manorapid Synergy against Vacciniavirus (Smallpox).
Study by Dr. M.H. Wolff of the Institute of Microbiology and Virology
University of Witten/Herdecke, Germany.
**Contributed References and reports to: C.D.C. Guidelines on Hand Hygiene. Oct. 25, 2002.
Virucidal testing against surrogate Smallpox virus, tested by standard suspension test according to euro normes effective in 30 seconds.
The efficacy of Manorapid Synergy for inactivation of the HIV virus.
Study conducted by the Ministry of Health and Family, The Institute of Public Health, Bucharest, Romania.
Virucidal testing to determine the efficacy of product against HIV virus.
The suitability of Manorapid Synergy for surgical hand disinfection
Study by Dr. M. Rotter, Hygiene Institute, Vienna, Austria. Protocal EN#12791
**Contributed References and reports to: C.D.C. Guidelines on Hand Hygiene. Oct. 25, 2002.
Adult volunteers' (20) hands are prepared and tested, according to EN#12791, for suitability for surgical hand disinfection.

Inactivation of non-enveloped viruses with Manorapid Synergy, test of activity against Norwalk like viruses.
Study by Dr. J. Steinmann, Scientific and Technical Head of Microlab GMBH.
Non-enveloped Norovirus tested utilizing quantitive suspension test, effective in 30 seconds.
Efficacy of Manorapid Synergy against Norwalk like viruses, using Feline Calici virus as a surrogate virus.
Study by Dr. J. Steinmann, Scientific and Technical Head of Microlab GMBH.
**Contributed References and reports to: C.D.C. Guidelines on Hand Hygiene. Oct. 25, 2002.
Highly resistant, extremely contagious Norovirus tested utilizing standard suspension test, effective in 30 seconds.

Manorapid Synergy, proven bactericidal and fungicidal antiseptic product.
Clinical tests by Dr. H.P. Werner of the Center for Hygiene and Safety.
Tested according to EN#1500 in vitro, product proven to be bactericidal, fungicidal in 30 seconds.
Virucidal efficacy of Manorapid Synergy test against Poliomyelitis virus.
Test by Dr. L. Dohner, Specialist for Microbiology and Infection Epidemiology.
Virucidal test against Polio virus strain, preformed according to D.V.V. suspension test in vitro.
Efficacy of Manorapid Synergy against highly resistant hydrophilic Study by J. Steinmann utilizing A.S.T.M. standard test.
Polio virus which is used as a benchmark organism representative of the entero virus family.

**Contributed References and reports to: C.D.C. Guidelines on Hand Hygiene. Oct. 25, 2002.
Human volunteers participated in study. American ASTM protocol used. Fingers were contaminated by viruses under practical conditions. Hepatitis A and Polio virus.
Testing for virucidal activity of Manorapid Synergy against enveloped and non-enveloped viruses.
Study by Prof. A. Galabov, M.D. Institute of Microbiology. Dept.of Virology.
Bulgarian Academy of Science. Sophia.
Adenovirus, Herpes 1 and 2, R.S.V., Hepatitis, tested according to standard suspension vitro testing.
Evaluation of Manorapid Synergy against feline calicavirus (surrogate of norovirus).
ASTM Standard Test (E 1838-02) by Dr. J. Steinmann.
**Contributed References and reports to: C.D.C. Guidelines on Hand Hygiene. Oct. 25, 2002
Adult volunteers' hands are contaminated with Norwalk virus. (American) ASTM 1838-02 test method to access the antiseptic, effective in 30 seconds.
In Vitro Cytotoxicity of Manorapid Synergy
Study by Prof. Axel Kramer, Institute Director; and Dr. Gerald Muller, Scientific Staff Member
Performed in Greifswald, Germany; September 28, 2004.


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